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摘自美国第七届基因治疗会议的文章  发贴心情 Post By:2004/5/4 14:07:07

ABSTRACTS THAT WILL BE PRESENTED IN THE 7TH ANNUAL MEETING OF THE AMERICAN SOCIETY OG GENE THERAPY, JUNE 2-6, MINNEAPOLIS, MINNESOTA : are there a real advance?

1) Micro-Utrophin as a Therapeutic Protein in rAAV Mediated Gene Therapy for Duchenne Muscular Dystrophy

2)Gender Differences in Transplantation Efficiency Using Muscle-Derived Stem Cells for Muscular Dystrophy

3) Therapeutic Antisense-Induced Exon Skipping for Duchenne Muscular Dystrophy

4) New Canine Models of Duchenne Muscular Dystrophy: Identification and Molecular Characterization

5) A Novel MiniDys-eGFP Fusion Gene for Developing Cell-Based Therapies of Duchenne Muscular Dystrophy

6) Expressing Full-Length Dystrophin in 50% Cardiomyocytes Corrects Cardiomyopathy in the Mdx Mouse Model for Duchenne Muscular Dystrophy 7) Expression of Normal Dystrophin Following Myoblast Transplantation to Duchenne Muscular Dystrophy Patients 8) rAAV-Mediated Gene Therapy To Treat Limb Girdle Muscular Dystrophy Type 2D (LGMD-2D)

9) Transgenic Expression of Dp116 in Muscle Does Not Ameliorate Dystrophy in mdx4cv Mice 10) Systemic Gene Transfer to Striated Muscles Using rAAV6 Vectors 11) Lentivirus Mediated Dystrophin Expression in mdx Muscles

12) Nucleofection and Phage phiC31 Integrase Mediate Stable Introduction of a Dystrophin Fusion Gene into Muscle Derived Stem Cell and Human Myoblasts 13) Successful AAV Vector-Mediated Gene Transfer into Canine Skeletal Muscle Required Suppression of Excess Immune Responses 14) An AAV Vector-Mediated Micro-Dystrophin Expression in Relatively Small Percentage of Dystrophin-Deficient mdx Myofibers Still Improved the mdx Phenotype through Compensatory Hypertrophy 15) Muscle-Derived Stem Cells Display an Extended, but Not Unlimited, Expansion Capability: Implication for Muscle Regeneration 16) Delivery of Igf-I and Dystrophin to Dystrophic mdx Muscle 17) Immunogenicity of Dystrophins Delivered to Mice by Gutted Adenoviral Vectors 18) Human Myoblast Deimmortalization Using Tat-Mediated Cre Recombinase Delivery 19) The Fetal Approach: A Novel Therapy for the Treatment of Musculo-Skeletal Disease 20) In Utero Intramuscular Delivery of a High-Capacity Adenoviral Vector Carrying a Full-Length Murine Dystrophin cDNA Provides Functional Benefit and Reassembly of the Dystrophin-Glycoprotein Complex in Hind Limb Muscles of mdx Mice


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